Abstract
An Al centre-powered graphitic nanozyme derived from a metal organic framework was first developed for a chemodynamic tumor treatment. By virtue of the rapid and efficient generation of ˙OH in the slightly acidic tumor microenvironment, this nanozyme afforded high anti-tumor efficacy both in living cells and in vivo.
MeSH terms
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Aluminum / administration & dosage*
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Aluminum / chemistry
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Animals
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Catalysis
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Cell Line, Tumor
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Cell Survival / drug effects
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Graphite / administration & dosage*
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Graphite / chemistry
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Humans
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Hydrogen Peroxide / pharmacology
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Hydrogen-Ion Concentration
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Hydroxyl Radical / metabolism
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Iron / administration & dosage*
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Iron / chemistry
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Methylene Blue / chemistry
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Mice, Nude
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Nitriles / administration & dosage*
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Nitriles / chemistry
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Tumor Microenvironment
Substances
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Nitriles
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Hydroxyl Radical
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cyanogen
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Graphite
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Hydrogen Peroxide
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Aluminum
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Iron
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Methylene Blue