Cutaneous Adenosquamous Carcinoma of the Scalp With Intestinal Phenotype

Am J Dermatopathol. 2020 Sep;42(9):e128-e130. doi: 10.1097/DAD.0000000000001671.

Abstract

Cutaneous adenosquamous carcinoma is a mixed, squamous and glandular, rare malignant tumor of the skin characterized by a mixed, squamous, and glandular differentiation. Few cases of this tumor have been so far reported, and even fewer have been thoroughly studied by immunohistochemistry. We report here an exceptional case of cutaneous adenosquamous carcinoma which showed immunohistochemically features of intestinal differentiation, namely because of the expression of keratin 20 and CDX2, a marker of gastrointestinal tumors.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Biomarkers, Tumor / analysis
  • CDX2 Transcription Factor / analysis
  • Carcinoma, Adenosquamous / chemistry
  • Carcinoma, Adenosquamous / pathology*
  • Carcinoma, Adenosquamous / surgery
  • Head and Neck Neoplasms / chemistry
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / surgery
  • Humans
  • Immunohistochemistry
  • Keratin-20 / analysis
  • Male
  • Phenotype
  • Scalp / chemistry
  • Scalp / pathology*
  • Scalp / surgery
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery

Substances

  • Biomarkers, Tumor
  • CDX2 Transcription Factor
  • CDX2 protein, human
  • KRT20 protein, human
  • Keratin-20