Elevated Salt Taste Threshold Is Associated with Increased Risk of Coronary Heart Disease

J Cardiovasc Transl Res. 2020 Dec;13(6):1016-1023. doi: 10.1007/s12265-020-10017-4. Epub 2020 May 6.

Abstract

High salt intake has been associated with coronary heart disease (CHD). The salt taste threshold could affect the salt intake, but its role in CHD is uncertain. We studied the association of salt taste threshold with CHD. In this study, the levels of salt detection threshold, recognition threshold, and taste preference were higher in CHD than in controls. The salt taste recognition threshold was significantly associated with CHD, and the significant association persisted after adjustment for traditional risk factors. Individuals with high level of salt taste recognition threshold were at a greater risk of CHD. Coincident occurrence of high level of salt taste recognition threshold, hypertension, and diabetes increased the risk of CHD. Thus, a high level of salt taste recognition threshold increases the risk of CHD, and the concurrence of high level of salt taste recognition threshold, hypertension, and diabetes further increases the risk of CHD.

Keywords: Coronary heart disease; Logistic regression analysis; Salt taste recognition threshold.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Case-Control Studies
  • China / epidemiology
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / epidemiology*
  • Diabetes Mellitus / diagnosis
  • Diabetes Mellitus / epidemiology*
  • Female
  • Food Preferences
  • Humans
  • Hypertension / diagnosis
  • Hypertension / epidemiology*
  • Incidence
  • Male
  • Middle Aged
  • Prevalence
  • Recognition, Psychology
  • Risk Assessment
  • Risk Factors
  • Sodium Chloride, Dietary / adverse effects*
  • Taste Perception*
  • Taste Threshold*

Substances

  • Sodium Chloride, Dietary