From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes

Vira Kravets; Richard K P Benninger

doi:10.1016/j.cmet.2020.04.012

From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes

Cell Metab. 2020 May 5;31(5):888-889. doi: 10.1016/j.cmet.2020.04.012.

Authors

Vira Kravets¹, Richard K P Benninger²

Affiliations

¹ Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Barbara Davis Center of Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
² Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Barbara Davis Center of Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: richard.benninger@cuanschutz.edu.

PMID: 32375060
DOI: 10.1016/j.cmet.2020.04.012

Abstract

Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlations indicate β cell compensation in type 2 diabetes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Diabetes Mellitus, Type 2* / genetics
Electrophysiological Phenomena
Electrophysiology
Humans
Insulin-Secreting Cells*
Transcriptome / genetics

Abstract

Publication types

MeSH terms

Grants and funding