Finally on Track: Interactions of Off-Track with Plex-Sema Pathway and Glycosaminoglycans

Shouqiang Cheng; Engin Özkan

doi:10.1016/j.str.2020.04.014

Finally on Track: Interactions of Off-Track with Plex-Sema Pathway and Glycosaminoglycans

Structure. 2020 May 5;28(5):492-494. doi: 10.1016/j.str.2020.04.014.

Authors

Shouqiang Cheng¹, Engin Özkan²

Affiliations

¹ Department of Biochemistry and Molecular Biology, and the Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637, USA.
² Department of Biochemistry and Molecular Biology, and the Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637, USA. Electronic address: eozkan@uchicago.edu.

PMID: 32375057
DOI: 10.1016/j.str.2020.04.014

Abstract

In this issue of Structure, Rozbesky et al. (2020) report evidence for direct molecular interactions between Drosophila OTK with Sema1a and glycosaminoglycans, providing insights for OTK's mode of action in axon guidance and possibly in Wnt signaling.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Axons
Carrier Proteins
Drosophila Proteins*
Drosophila*
Glycosaminoglycans

Substances

Carrier Proteins
Drosophila Proteins
Glycosaminoglycans

Grants and funding

R01 NS097161/NS/NINDS NIH HHS/United States