Thermal Activation of Thin Filaments in Striated Muscle

Shuya Ishii; Kotaro Oyama; Seine A Shintani; Fuyu Kobirumaki-Shimozawa; Shin'ichi Ishiwata; Norio Fukuda

doi:10.3389/fphys.2020.00278

Thermal Activation of Thin Filaments in Striated Muscle

Front Physiol. 2020 Apr 16:11:278. doi: 10.3389/fphys.2020.00278. eCollection 2020.

Authors

Shuya Ishii^{1

2}, Kotaro Oyama^{2

3}, Seine A Shintani⁴, Fuyu Kobirumaki-Shimozawa¹, Shin'ichi Ishiwata⁵, Norio Fukuda¹

Affiliations

¹ Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan.
² Quantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology, Gunma, Japan.
³ PRESTO, Japan Science and Technology Agency, Saitama, Japan.
⁴ Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan.
⁵ Department of Physics, Faculty of Science and Engineering, Waseda University, Tokyo, Japan.

Abstract

In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca²⁺ concentration. During Ca²⁺ transients, Ca²⁺-binding to troponin C shifts the "on-off" equilibrium of the thin filament state toward the "on" sate, promoting actomyosin interaction. Likewise, recent studies have revealed that the thin filament state is under the influence of temperature; viz., an increase in temperature increases active force production. In this short review, we discuss the effects of temperature on the contractile performance of mammalian striated muscle at/around body temperature, focusing especially on the temperature-dependent shift of the "on-off" equilibrium of the thin filament state.

Keywords: Ca2+ sensitivity; actomyosin; cardiac muscle; skeletal muscle; temperature; tropomyosin; troponin.

Publication types

Review