Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging

Yohei Kondo; Hiroshi Nonaka; Yoichi Takakusagi; Shinsuke Sando

doi:10.1002/anie.201915718

Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging

Angew Chem Int Ed Engl. 2021 Jun 25;60(27):14779-14799. doi: 10.1002/anie.201915718. Epub 2021 Feb 2.

Authors

Yohei Kondo¹, Hiroshi Nonaka², Yoichi Takakusagi^{3

4}, Shinsuke Sando^{1

5}

Affiliations

¹ Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
² Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto University Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
³ Institute of Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba-city, 263-8555, Japan.
⁴ National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba-city, 263-8555, Japan.
⁵ Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

PMID: 32372551
DOI: 10.1002/anie.201915718

Abstract

Nuclear hyperpolarization has emerged as a method to dramatically enhance the sensitivity of NMR spectroscopy. By application of this powerful tool, small molecules with stable isotopes have been used for highly sensitive biomedical molecular imaging. The recent development of molecular probes for hyperpolarized in vivo analysis has demonstrated the ability of this technique to provide unique metabolic and physiological information. This review presents a brief introduction of hyperpolarization technology, approaches to the rational design of molecular probes for hyperpolarized analysis, and examples of molecules that have met with success in vitro or in vivo.

Keywords: NMR spectroscopy; biosensors; chemical probes; dynamic nuclear polarization; hyperpolarization.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Magnetic Resonance Spectroscopy
Molecular Imaging*
Molecular Probes / chemical synthesis*
Molecular Probes / chemistry

Substances

Molecular Probes