Cytotoxic Meroterpenoids from the Fungus Alternaria sp. JJY-32

Chem Biodivers. 2020 Jul;17(7):e2000226. doi: 10.1002/cbdv.202000226. Epub 2020 Jul 7.

Abstract

Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY-32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL-60 and HO8910 cells with IC50 values of 7.54 and 20.32 μm.

Keywords: Alternaria sp.; cytotoxicity; meroterpenoids; tricycloalternarene.

MeSH terms

  • Alternaria / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Circular Dichroism
  • Density Functional Theory
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Conformation
  • Structure-Activity Relationship
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Terpenes
  • tricycloalternarene I