Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY-32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL-60 and HO8910 cells with IC50 values of 7.54 and 20.32 μm.
Keywords: Alternaria sp.; cytotoxicity; meroterpenoids; tricycloalternarene.
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