Study on the Effect of Lidocaine in the Cuff for Endotracheal Tube in Vitro and in Vivo

J Craniofac Surg. 2020 Sep;31(6):1721-1723. doi: 10.1097/SCS.0000000000006469.

Abstract

Objective: The purpose of this research was to investigate the effectiveness on postoperative pharyngalgia of filling the endotracheal catheter (ETC) cuffs with air, double distilled water, 2% lidocaine hydrochloride, and 1.73% lidocaine carbonate.

Methods: A group of 80 female patients were divided into 4 groups randomly. The ETC cuffs were filled with air (Group A), double distilled water (Group B), 2% lidocaine hydrochloride (Group C), and 1.73% lidocaine carbonate (Group D) after endotracheal intubation in corresponding patients. Sore throat, hoarseness, bucking, perioperative hemodynamic changes were examined in all participants.

Results: The Group D had significantly less severity of POST (P < 0.05), postoperative hoarseness (P < 0.05) and bucking on emergence from general anesthesia (P < 0.01) than patients from other groups. The Group D reported significantly less hemodynamic changes after extubation 1, 5, 10 minutes (P < 0.05).

Conclusion: Lidocaine carbonate injected into the ETC cuffs decreased the severity of postoperative pharyngalgia, postoperative hoarseness and bucking on emergence from general anesthesia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Anesthesia, General
  • Female
  • Hoarseness / etiology
  • Humans
  • Intubation, Intratracheal
  • Lidocaine / adverse effects
  • Lidocaine / pharmacology*
  • Pharyngitis / etiology
  • Postoperative Complications
  • Postoperative Period

Substances

  • Lidocaine