Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Kejing Shi; Rodrigo Aviles-Espinosa; Elizabeth Rendon-Morales; Lisa Woodbine; Mohammed Maniruzzaman; Ali Nokhodchi

doi:10.1016/j.colsurfb.2020.111068

Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Colloids Surf B Biointerfaces. 2020 Apr 21:192:111068. doi: 10.1016/j.colsurfb.2020.111068. Online ahead of print.

Authors

Kejing Shi¹, Rodrigo Aviles-Espinosa², Elizabeth Rendon-Morales², Lisa Woodbine³, Mohammed Maniruzzaman⁴, Ali Nokhodchi⁵

Affiliations

¹ Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, UK.
² Robotics and Mechatronics Systems Research Centre, School of Engineering and Informatics, University of Sussex, Falmer, Brighton, BN1 9RH, UK.
³ Sussex Centre for Genome Damage and Stability, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.
⁴ Pharmaceutical Engineering and 3D Printing Lab, Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA. Electronic address: M.Maniruzzaman@austin.utexas.edu.
⁵ Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QJ, UK. Electronic address: a.nokhodchi@sussex.ac.uk.

PMID: 32371300
DOI: 10.1016/j.colsurfb.2020.111068

Abstract

With the growing demand for personalized medicine and medical devices, the impact of on-demand triggerable (e.g., via magnetic fields) drug delivery systems increased significantly in recent years. The three-dimensional (3D) printing technology has already been applied in the development of personalized dosage forms because of its high-precision and accurate manufacturing ability. In this study, a novel magnetically triggerable drug delivery device composed of a magnetic polydimethylsiloxane (PDMS) sponge cylinder and a 3D printed reservoir was designed, fabricated and characterized. This system can realize a switch between "on" and "off" state easily through the application of different magnetic fields and from different directions. Active and repeatable control of the localized drug release could be achieved by the utilization of magnetic fields to this device due to the shrinking extent of the macro-porous magnetic sponge inside. The switching "on" state of drug-releasing could be realized by the magnetic bar contacted with the side part of the device because the times at which 50%, 80% and 90% (w/w) of the drug were dissolved are observed to be 20, 55 and 140 min, respectively. In contrast, the switching "off" state of drug-releasing could be realized by the magnetic bar placed at the bottom of the device as only 10% (w/w) of the drug could be released within 12 h. An anti-cancer substance, 5-fluorouracil (FLU), was used as the model drug to illustrate the drug release behaviour of the device under different strengths of magnetic fields applied. In vitro cell culture studies also demonstrated that the stronger the magnetic field applied, the higher the drug release from the deformed PDMS sponge cylinder and thus more obvious inhibition effects on Trex cell growth. All results confirmed that the device can provide a safe, long-term, triggerable and reutilizable way for localized disease treatment such as cancer.

Keywords: 3D printing; 5-fluorouracil; FDM; carbonyl iron; fused deposition modelling; iron oxide; magnetic field; personalized medicine; polydimethylsiloxane sponge; triggerable drug delivery system.