Impact of the Allergy Clarification for Cefazolin Evidence-based Prescribing Tool on Receipt of Preferred Perioperative Prophylaxis: An Interrupted Time Series Study

Philip W Lam; Payam Tarighi; Marion Elligsen; Avery B Nathens; Daniel Riegert; Jordan Tarshis; Jerome A Leis

doi:10.1093/cid/ciaa516

Impact of the Allergy Clarification for Cefazolin Evidence-based Prescribing Tool on Receipt of Preferred Perioperative Prophylaxis: An Interrupted Time Series Study

Clin Infect Dis. 2020 Dec 31;71(11):2955-2957. doi: 10.1093/cid/ciaa516.

Authors

Philip W Lam^{1

2}, Payam Tarighi³, Marion Elligsen⁴, Avery B Nathens³, Daniel Riegert⁵, Jordan Tarshis⁵, Jerome A Leis^{1

2

6}

Affiliations

¹ Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
² Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
³ Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁴ Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁵ Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁶ Centre for Quality Improvement and Patient Safety, University of Toronto, Toronto, Ontario, Canada.

PMID: 32364587
DOI: 10.1093/cid/ciaa516

Abstract

Implementation of a perioperative allergy and antibiotic assessment tool in patients with reported beta-lactam allergy resulted in a pronounced and sustained increase in perioperative cefazolin use. This intervention could result in improved efficiencies surrounding perioperative antibiotic administration and possible reductions in surgical site infection rates.

Keywords: beta-lactam allergy; penicillin allergy; surgical site infection.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Antibiotic Prophylaxis
Cefazolin* / therapeutic use
Drug Hypersensitivity*
Humans
Interrupted Time Series Analysis
Penicillins
Surgical Wound Infection / drug therapy
Surgical Wound Infection / prevention & control
beta-Lactams

Substances

Anti-Bacterial Agents
Penicillins
beta-Lactams
Cefazolin