Abstract
Convenient strategies to transform regular liposomes or nano-micelles into multifunctional theranostics would be highly valuable in cancer therapy. Herein, we developed an amphiphilic fluorinated porphyrin dendrimer as a multifunctional "add-on" module which would self-assemble onto liposomal drug delivery systems and conveniently transform the liposomes into novel theranostics. Through cancer cells and murine xenograft tumor model assays, the theranostics showed valuable fluorescence/19F magnetic resonance dual modal imaging and highly efficient chemo-photodynamic therapy. The modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Delivery Systems
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Drug Screening Assays, Antitumor
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Halogenation
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Hep G2 Cells
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Humans
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Liposomes / chemistry
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Liver Neoplasms, Experimental / drug therapy
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Liver Neoplasms, Experimental / metabolism
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Liver Neoplasms, Experimental / pathology
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Molecular Structure
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Optical Imaging*
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Particle Size
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Photochemotherapy*
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Porphyrins / chemical synthesis
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Porphyrins / chemistry
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Porphyrins / pharmacology*
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Surface Properties
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Surface-Active Agents / chemical synthesis
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Surface-Active Agents / chemistry
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Surface-Active Agents / pharmacology*
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Theranostic Nanomedicine*
Substances
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Antineoplastic Agents
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Liposomes
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Porphyrins
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Surface-Active Agents