Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

J Mater Chem B. 2020 May 27;8(20):4469-4474. doi: 10.1039/d0tb00083c.

Abstract

Convenient strategies to transform regular liposomes or nano-micelles into multifunctional theranostics would be highly valuable in cancer therapy. Herein, we developed an amphiphilic fluorinated porphyrin dendrimer as a multifunctional "add-on" module which would self-assemble onto liposomal drug delivery systems and conveniently transform the liposomes into novel theranostics. Through cancer cells and murine xenograft tumor model assays, the theranostics showed valuable fluorescence/19F magnetic resonance dual modal imaging and highly efficient chemo-photodynamic therapy. The modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Delivery Systems
  • Drug Screening Assays, Antitumor
  • Halogenation
  • Hep G2 Cells
  • Humans
  • Liposomes / chemistry
  • Liver Neoplasms, Experimental / drug therapy
  • Liver Neoplasms, Experimental / metabolism
  • Liver Neoplasms, Experimental / pathology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Molecular Structure
  • Optical Imaging*
  • Particle Size
  • Photochemotherapy*
  • Porphyrins / chemical synthesis
  • Porphyrins / chemistry
  • Porphyrins / pharmacology*
  • Surface Properties
  • Surface-Active Agents / chemical synthesis
  • Surface-Active Agents / chemistry
  • Surface-Active Agents / pharmacology*
  • Theranostic Nanomedicine*

Substances

  • Antineoplastic Agents
  • Liposomes
  • Porphyrins
  • Surface-Active Agents