Selective N7 Alkylation of 7-Azaindazoles

J Org Chem. 2020 Jun 5;85(11):7558-7564. doi: 10.1021/acs.joc.0c00722. Epub 2020 May 18.

Abstract

A general and mild procedure for alkylation of 7-azaindazoles at the N7 position using alkyl halides in butanone is reported, which requires no additives such as acids or bases. The scope of the reaction regarding substituents on 7-azaindazoles and the alkyl electrophiles is presented.