How the COVID-19 Overcomes the Battle? An Approach to Virus Structure

Iran J Kidney Dis. 2020 May;14(3):167-172.

Abstract

Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARSCoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.

Publication types

  • Review

MeSH terms

  • Animals
  • Betacoronavirus* / genetics
  • Betacoronavirus* / immunology
  • COVID-19
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / virology*
  • Gene Order
  • Genome, Viral / genetics*
  • Humans
  • Immune System / virology*
  • Pandemics
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / virology*
  • SARS-CoV-2
  • Severe acute respiratory syndrome-related coronavirus / genetics
  • Severe acute respiratory syndrome-related coronavirus / immunology
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / metabolism
  • Viral Proteins / genetics*
  • Viral Proteins / metabolism*
  • Viral Structures / genetics
  • Virus Internalization

Substances

  • Spike Glycoprotein, Coronavirus
  • Viral Proteins
  • spike protein, SARS-CoV-2