Abstract
Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARSCoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.
MeSH terms
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Animals
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Betacoronavirus* / genetics
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Betacoronavirus* / immunology
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COVID-19
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Coronavirus Infections / immunology*
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Coronavirus Infections / virology*
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Gene Order
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Genome, Viral / genetics*
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Humans
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Immune System / virology*
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Pandemics
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Pneumonia, Viral / immunology*
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Pneumonia, Viral / virology*
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SARS-CoV-2
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Severe acute respiratory syndrome-related coronavirus / genetics
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Severe acute respiratory syndrome-related coronavirus / immunology
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / metabolism
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Viral Proteins / genetics*
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Viral Proteins / metabolism*
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Viral Structures / genetics
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Virus Internalization
Substances
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Spike Glycoprotein, Coronavirus
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Viral Proteins
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spike protein, SARS-CoV-2