Maresin-1 resolution with RORα and LGR6

Prog Lipid Res. 2020 Apr:78:101034. doi: 10.1016/j.plipres.2020.101034. Epub 2020 Apr 30.

Abstract

Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6). RORα is a nuclear receptor and LGR6 is a plasma membrane GPCR. Identification of two different molecular targets raises the following question: What are the pro-resolving functions of each receptor in inflammation resolution, host defense, tissue homeostasis, and wound healing? In this article, I review the new targets from the point of view of pharmacology and maresin-1 resolution along with intracellular signaling molecules.

Keywords: G protein-coupled receptor; Inflammation; LGR6; Maresin-1; Nuclear receptor; RORα; Resolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Docosahexaenoic Acids / chemistry
  • Docosahexaenoic Acids / pharmacology*
  • Humans
  • Inflammation Mediators / chemistry
  • Inflammation Mediators / pharmacology*
  • Mice
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / antagonists & inhibitors*
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / metabolism
  • Receptors, G-Protein-Coupled / antagonists & inhibitors*
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction / drug effects

Substances

  • 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid
  • Inflammation Mediators
  • LGR6 protein, human
  • Lgr6 protein, mouse
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Receptors, G-Protein-Coupled
  • Docosahexaenoic Acids