Caffeic acid oligomers from Mesona chinensis and their In Vitro antiviral activities

Fitoterapia. 2020 Jul:144:104603. doi: 10.1016/j.fitote.2020.104603. Epub 2020 Apr 28.

Abstract

The phytochemical study of the aerial part of Mesona chinensis led to the isolation of five new caffeic acid oligomers (1-5), as well as four known analogues (6-9). The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, chemical method, and quantum-chemical electronic circular dichroism (ECD) calculation. Among the isolates, compound 7 showed significant in vitro antiviral activity on respiratory syncytial virus (RSV).

Keywords: Anti-RSV activity; Caffeic acid oligomer; Mesona chinensis.

MeSH terms

  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Caffeic Acids / isolation & purification
  • Caffeic Acids / pharmacology*
  • Cell Line, Tumor
  • China
  • Humans
  • Lamiaceae / chemistry*
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Components, Aerial / chemistry
  • Respiratory Syncytial Virus, Human / drug effects*

Substances

  • Antiviral Agents
  • Caffeic Acids
  • Phytochemicals
  • caffeic acid