Anti-inflammatory principles from Lindera aggregata

Ping-Chung Kuo; Yi-Hung Wu; Hsin-Yi Hung; Sio-Hong Lam; Guo-Hao Ma; Liang-Mou Kuo; Tsong-Long Hwang; Daih-Huang Kuo; Tian-Shung Wu

doi:10.1016/j.bmcl.2020.127224

Anti-inflammatory principles from Lindera aggregata

Bioorg Med Chem Lett. 2020 Jul 1;30(13):127224. doi: 10.1016/j.bmcl.2020.127224. Epub 2020 Apr 27.

Authors

Ping-Chung Kuo¹, Yi-Hung Wu², Hsin-Yi Hung¹, Sio-Hong Lam¹, Guo-Hao Ma³, Liang-Mou Kuo⁴, Tsong-Long Hwang⁵, Daih-Huang Kuo⁶, Tian-Shung Wu⁷

Affiliations

¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
² Hsinhua Forest Station, The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan.
³ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
⁴ Department of General Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi 613, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
⁵ Graduate Institute of Natural Products, College of Medicine, Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Industry of Human Ecology, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
⁶ Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan.
⁷ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.

PMID: 32359855
DOI: 10.1016/j.bmcl.2020.127224

Abstract

Four new sesquiterpenes (1-4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC₅₀ values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Keywords: Alkaloid; Anti-inflammatory; Benzenoid glycoside; Elastase release; Sesquiterpene; Superoxide anion generation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Humans
Lindera / chemistry*
Molecular Structure
Neutrophils / drug effects
Pancreatic Elastase / metabolism
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Superoxides / metabolism

Substances

Anti-Inflammatory Agents
Sesquiterpenes
Superoxides
Pancreatic Elastase