NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic

Zhenhua Hu; Wen-Hua Chen; Jie Tian; Zhen Cheng

doi:10.1016/j.molmed.2020.02.003

NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic

Trends Mol Med. 2020 May;26(5):469-482. doi: 10.1016/j.molmed.2020.02.003. Epub 2020 Mar 18.

Authors

Zhenhua Hu¹, Wen-Hua Chen², Jie Tian³, Zhen Cheng⁴

Affiliations

¹ CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
² School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, PR China; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
³ CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China; School of Life Science and Technology, Xidian University, Xian 710071, PR China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, PR China. Electronic address: jie.tian@ia.ac.cn.
⁴ Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: zcheng@stanford.edu.

PMID: 32359478
DOI: 10.1016/j.molmed.2020.02.003

Abstract

Near-IR fluorescence imaging (NIRFI) is a highly promising technique for improving cancer theranostics in the era of precision medicine. Through the combination with cutting-edge bionanotechnologies, the potential of NIRFI can be greatly broadened. A variety of novel NIRF nanoprobes has been developed with ultimate goals of addressing unmet medical needs. Here, we present recent breakthroughs on the fundamental aspects of NIRFI, such as imaging at long wavelengths (1000-1700 nm), and the use of new approaches (X-rays, chemiluminescence, radioluminescence, etc.) for the excitation of novel nanoprobes. Within two decades, research on NIRF nanoprobes has translated to clinical trials and it will further translate to cancer management.

Keywords: NIR-II; NIRF; cancer; molecular imaging; nanoprobe; theranostics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Molecular Imaging / methods*
Nanoparticles / chemistry*
Neoplasms / diagnostic imaging*
Optical Imaging / methods*
Spectroscopy, Near-Infrared / methods*