FABP4: A New Player in Obesity-Associated Breast Cancer

Jun Zeng; Edward R Sauter; Bing Li

doi:10.1016/j.molmed.2020.03.004

FABP4: A New Player in Obesity-Associated Breast Cancer

Trends Mol Med. 2020 May;26(5):437-440. doi: 10.1016/j.molmed.2020.03.004. Epub 2020 Apr 8.

Authors

Jun Zeng¹, Edward R Sauter², Bing Li³

Affiliations

¹ School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA.
² Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
³ Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA. Electronic address: b.li@louisville.edu.

Abstract

Obesity is known to increase breast cancer incidence and mortality, but the underlying mechanisms remain unsolved. Recent studies demonstrate that adipose fatty acid binding protein (FABP4) promotes obesity-associated breast cancer development, thus suggesting FABP4 as a novel player linking obesity and breast cancer risk.

Keywords: Adipose fatty acid binding protein; Breast cancer; Obesity; Tumor associated macrophages.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Breast Neoplasms / etiology
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Fatty Acid-Binding Proteins / metabolism*
Female
Humans
Obesity / complications
Obesity / metabolism*
Obesity / pathology

Substances

FABP4 protein, human
Fatty Acid-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding