Interleukin-17: A Social Cytokine

Casper C Hoogenraad; Lorena Riol-Blanco

doi:10.1016/j.cell.2020.03.060

Interleukin-17: A Social Cytokine

Cell. 2020 Apr 30;181(3):517-519. doi: 10.1016/j.cell.2020.03.060.

Authors

Casper C Hoogenraad¹, Lorena Riol-Blanco²

Affiliations

¹ Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.
² Department of Immunology, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address: riol-blanco.lorena@gene.com.

PMID: 32359435
DOI: 10.1016/j.cell.2020.03.060

Abstract

Some children with autism spectrum disorder (ASD) show behavioral improvements when experiencing inflammation accompanied by fever; however, little is known about the mechanisms that underlie these beneficial effects. In a recent issue of Nature, Reed and colleagues demonstrate that the production of interleukin-17 (IL-17) during inflammation promotes social behavior in mouse models of neurodevelopmental disorders.

Publication types

Comment

MeSH terms

Animals
Autism Spectrum Disorder*
Child
Cytokines
Humans
Interleukin-17
Mice
Neurodevelopmental Disorders*
Social Behavior

Substances

Cytokines
Interleukin-17