Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan

In Vivo. 2020 May-Jun;34(3):1111-1116. doi: 10.21873/invivo.11882.

Abstract

Background/aim: The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese.

Materials and methods: A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.

Results: Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls.

Conclusion: IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese.

Keywords: Breast cancer; IL-4; Taiwan; genotype; polymorphism.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Asian People / genetics
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Interleukin-4 / genetics*
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic
  • Risk Assessment
  • Taiwan

Substances

  • IL4 protein, human
  • Interleukin-4