Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar

Gonzalo Del Monte-Nieto; Jens W Fischer; Daniel J Gorski; Richard P Harvey; Jason C Kovacic

doi:10.1016/j.jacc.2020.03.024

Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar

J Am Coll Cardiol. 2020 May 5;75(17):2169-2188. doi: 10.1016/j.jacc.2020.03.024.

Authors

Gonzalo Del Monte-Nieto¹, Jens W Fischer², Daniel J Gorski³, Richard P Harvey⁴, Jason C Kovacic⁵

Affiliations

¹ Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia. Electronic address: gonzalo.delmontenieto@monash.edu.
² Institut für Pharmakologie und Klinische Pharmakologie, University Hospital, Heinrich-Heine-University Düsseldorf, Germany; Cardiovascular Research Institute Düsseldorf, University Hospital, Heinrich-Heine-University Düsseldorf, Germany. Electronic address: jens.fischer@uni-duesseldorf.de.
³ Institut für Pharmakologie und Klinische Pharmakologie, University Hospital, Heinrich-Heine-University Düsseldorf, Germany; Cardiovascular Research Institute Düsseldorf, University Hospital, Heinrich-Heine-University Düsseldorf, Germany.
⁴ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia; School of Biotechnology and Biomolecular Science, University of New South Wales, New South Wales, Australia. Electronic address: r.harvey@victorchang.edu.au.
⁵ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: jason.kovacic@mountsinai.org.

Abstract

The extracellular matrix (ECM) is the noncellular component of tissues in the cardiovascular system and other organs throughout the body. It is formed of filamentous proteins, proteoglycans, and glycosaminoglycans, which extensively interact and whose structure and dynamics are modified by cross-linking, bridging proteins, and cleavage by matrix degrading enzymes. The ECM serves important structural and regulatory roles in establishing tissue architecture and cellular function. The ECM of the developing heart has unique properties created by its emerging contractile nature; similarly, ECM lining blood vessels is highly elastic in order to sustain the basal and pulsatile forces imposed on their walls throughout life. In this part 1 of a 4-part JACC Focus Seminar, we focus on the role, function, and basic biology of the ECM in both heart development and in the adult.

Keywords: cardiovascular; collagen; development; homeostasis; matrix.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiology / education*
Cardiovascular System / cytology*
Cardiovascular System / growth & development*
Cardiovascular System / metabolism
Extracellular Matrix / physiology*
Homeostasis / physiology
Humans
Proteoglycans / metabolism

Substances

Proteoglycans

Abstract

Publication types

MeSH terms

Substances

Grants and funding