Multiple Measures of Mineral Metabolism Were Associated With Renal Function in Chinese Centenarians: A Cross-Sectional Study

Shihui Fu; Haotian Yu; Yulong Li; Faqin Lv; Juelin Deng; Fu Zhang; Fuxin Luan; Yali Zhao; Yao Yao

doi:10.3389/fmed.2020.00120

Multiple Measures of Mineral Metabolism Were Associated With Renal Function in Chinese Centenarians: A Cross-Sectional Study

Front Med (Lausanne). 2020 Apr 15:7:120. doi: 10.3389/fmed.2020.00120. eCollection 2020.

Authors

Shihui Fu^{1

2}, Haotian Yu³, Yulong Li¹, Faqin Lv⁴, Juelin Deng², Fu Zhang³, Fuxin Luan³, Yali Zhao³, Yao Yao^{5

6}

Affiliations

¹ Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
² Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
³ Central Laboratory, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
⁴ Department of Ultrasound, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
⁵ Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, NC, United States.
⁶ Center for Healthy Ageing and Development Studies, National School of Development, Peking University, Beijing, China.

Abstract

Background: Chronic kidney disease (CKD) constitutes a public health issue that is estimated to affect more than 10% of global population. Over 100 million people have CKD in China. For the first time, this cross-sectional study was designed to determine whether multiple measures of mineral metabolism had a significant association with renal function in Chinese centenarians. Methods: China Hainan Centenarian Cohort Study was conducted in 18 cities and counties of Hainan Province, China. It utilized the standard methodology for home interview and blood analyses in 750 centenarians including 608 females and 142 males. Results: All centenarians have a median (range) age of 102 (100-115) years, and median (range) level of estimated glomerular filtration rate (eGFR) was 63 (16-138) ml/min/1.73 m². There were 318 centenarians (42.4%) with eGFR levels <60 ml/min/1.73 m². In simple correlation and multivariate linear regression analyses, serum phosphorus, osteocalcin, β-crosslaps, total procollagen type 1 N-terminal propeptide (TP1NP), and parathyroid hormone (PTH) levels were negatively associated with eGFR levels (P < 0.05 for all). Conclusion: The current study supported that serum phosphorus, osteocalcin, β-crosslaps, TP1NP, and PTH levels were negatively associated with eGFR levels, and demonstrated a significant association between multiple measures of mineral metabolism and renal function in Chinese centenarians.

Keywords: Chinese centenarians; estimated glomerular filtration rate; mineral metabolism; parathyroid hormone; total procollagen type 1 N-terminal propeptide.