New and known phenylpropanoid glycosides from mountain cultivated ginseng

Nat Prod Res. 2021 Nov;35(21):3992-3998. doi: 10.1080/14786419.2020.1753051. Epub 2020 Apr 29.

Abstract

Two new phenylpropanoid glycosides elucidated as 2,6-dimethoxyphenyl-4-propylene-1-O-β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside (1) and 2-methoxyphenyl-4-propylene-1-O-β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside (2), along with three known phenylpropanoid glycosides (3-5) were isolated from Mountain Cultivated Ginseng. The structures of compounds 1-5 were elucidated on the basis of comprehensive spectroscopic data including 1D, 2D NMR spectra, and MS. In addition, in vitro cytotoxicity of all the isolated compounds was evaluated against HELA cell.

Keywords: Panax ginseng C.A. Meyer; cytotoxicity; mountain cultivated ginseng; phenylpropanoid glycoside.

MeSH terms

  • Glycosides* / pharmacology
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Panax*

Substances

  • Glycosides