Abstract
Mitigating inflammation is clearly important in cancer prevention and control. Traditionally, pharmaceuticals have taken the lead in this problem. In an attempt to 'head them off at the pass', this Forum takes a hard look at the concept of 'better living through chemicals' and limiting proinflammatory chemicals entering the body.
Keywords:
COX-2; NSAIDs; PPARδ; cancer initiation; cancer progression; chemical exposure; inflammation.
Published by Elsevier Inc.
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Carcinogens, Environmental / adverse effects*
-
Carcinogens, Environmental / standards
-
Cyclooxygenase 2 / genetics
-
Cyclooxygenase 2 / metabolism
-
Environmental Exposure / adverse effects*
-
Environmental Exposure / prevention & control
-
Environmental Exposure / standards
-
Gene Expression Regulation, Neoplastic / drug effects
-
Gene Expression Regulation, Neoplastic / immunology
-
Holistic Health*
-
Humans
-
Inflammation / chemically induced
-
Inflammation / drug therapy
-
Inflammation / immunology
-
Inflammation / prevention & control*
-
Mutation / drug effects
-
Neoplasms / drug therapy
-
Neoplasms / genetics
-
Neoplasms / immunology
-
Neoplasms / prevention & control*
-
PPAR delta / antagonists & inhibitors
-
PPAR delta / metabolism
-
Signal Transduction / drug effects
-
Signal Transduction / genetics
-
Signal Transduction / immunology
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Carcinogens, Environmental
-
PPAR delta
-
Cyclooxygenase 2