Abstract
Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
Keywords:
ACE2; COVID-19; Lung Cancer; SARS-CoV-2; TMPRSS2.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma of Lung / complications*
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Adenocarcinoma of Lung / genetics
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Angiotensin-Converting Enzyme 2
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Animals
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Betacoronavirus*
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COVID-19
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Carcinoma, Squamous Cell / complications*
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Carcinoma, Squamous Cell / genetics
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Cell Line
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Coronavirus Infections / etiology*
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Coronavirus Infections / genetics
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Disease Susceptibility
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic
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Humans
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Lung Neoplasms / complications*
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Lung Neoplasms / genetics
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Mice
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Mice, Transgenic
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Pandemics
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Peptidyl-Dipeptidase A / biosynthesis
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Peptidyl-Dipeptidase A / genetics*
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Pneumonia, Viral / etiology*
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Pneumonia, Viral / genetics
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SARS-CoV-2
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Serine Endopeptidases / biosynthesis
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Serine Endopeptidases / genetics*
Substances
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Peptidyl-Dipeptidase A
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ACE2 protein, human
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Ace2 protein, mouse
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Angiotensin-Converting Enzyme 2
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Serine Endopeptidases
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TMPRSS2 protein, human