The action of a BK channel opener

J Gen Physiol. 2020 Jun 1;152(6):e202012571. doi: 10.1085/jgp.202012571.

Abstract

Rockman et al. in this issue of JGP describe how NS11021 opens BK channels, which make the compound a better tool to probe physiological roles and gating mechanisms of BK channels.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Large-Conductance Calcium-Activated Potassium Channels*
  • Muscle, Smooth
  • Tetrazoles*
  • Thiourea / analogs & derivatives

Substances

  • 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea
  • Large-Conductance Calcium-Activated Potassium Channels
  • Tetrazoles
  • Thiourea