(Health-Related) Quality of Life as an Outcome in Studies of Axial Spondyloarthritis

Uta Kiltz; David Kiefer; Annelies Boonen

doi:10.1016/j.rdc.2020.01.017

(Health-Related) Quality of Life as an Outcome in Studies of Axial Spondyloarthritis

Rheum Dis Clin North Am. 2020 May;46(2):379-393. doi: 10.1016/j.rdc.2020.01.017.

Authors

Uta Kiltz¹, David Kiefer², Annelies Boonen³

Affiliations

¹ Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Claudiusstr 45, Herne 44649, Germany. Electronic address: uta.kiltz@elisabethgruppe.de.
² Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Claudiusstr 45, Herne 44649, Germany.
³ Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Centre (MUMC+), Maastricht and Care and Public Health Research Institute (CAPHRI), Maastricht University, P. Debeyelaan 25, Maastricht 6229 HX, the Netherlands.

PMID: 32340709
DOI: 10.1016/j.rdc.2020.01.017

Abstract

The most prevalent health concerns in patients with axial spondyloarthritis (axSpA) include spinal stiffness, spinal pain, mobility limitations, fatigue, and disturbed sleep. Many patients experience impairments related to extraspinal disease, extra-articular disease, or drug side effects. To capture overall life impact, self-reported measurement instruments assessing health-related quality of life (HRQoL) have been developed. This article summarizes the literature on relevant concepts and frameworks when measuring overall health or HRQoL, available measures assessing this outcome in axSpA, the hierarchical relations between overall health/HRQoL and specific axSpA impairments, and the role of context when interpreting interventions for overall health or HRQoL outcomes.

Keywords: Axial spondyloarthritis; Contextual factors; Functioning and health; Health-related quality of life; Life satisfaction.

Publication types

Review

MeSH terms

Humans
Patient Reported Outcome Measures
Quality of Life*
Self Report
Spondylarthritis* / therapy
Treatment Outcome