Association of history of adverse childhood experiences with irritable bowel syndrome (IBS) in individuals with mood disorders

Joshua D Rosenblat; Rodrigo B Mansur; Elisa Brietzke; Sidney H Kennedy; Andre F Carvalho; Yena Lee; Mehala Subramaniapillai; David J Muzina; Roman Dale; Jocelyn K Tamura; Leanna M W Lui; Caroline Park; Lee Phan; Raluca M Tuineag; Roger S McIntyre

doi:10.1016/j.psychres.2020.112967

Association of history of adverse childhood experiences with irritable bowel syndrome (IBS) in individuals with mood disorders

Psychiatry Res. 2020 Jun:288:112967. doi: 10.1016/j.psychres.2020.112967. Epub 2020 Apr 17.

Authors

Affiliations

¹ Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
² Department of Psychiatry, Providence Care Hospital, Department of Psychiatry, Queen's University, Kingston, ON, Canada; Department of Psychiatry, Universidade federal de São Paulo, São Paulo, Brazil.
³ Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Depression and Suicide Studies, St. Michael's Hospital, Toronto, ON, Canada.
⁴ Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
⁵ Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
⁶ Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.
⁷ Clinical Operations, Quality and Health Services, Medical Mutual of Ohio, USA.
⁸ Lutheran Hospital, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
⁹ Neurosciences & Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁰ Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address: roger.mcintyre@uhn.ca.

PMID: 32339805
DOI: 10.1016/j.psychres.2020.112967

Abstract

The objective of the current study was to assess the association between adverse childhood experiences (ACEs) and irritable bowel syndrome (IBS) in mood disorder patients. Self-report data from the International Mood Disorders Collaborative Project were cross-sectionally analyzed to compare rates of IBS in participants with confirmed diagnoses of major depressive disorder (MDD; n = 279) or bipolar disorder (BD; n = 219). Data was sub-grouped and compared based on history of ACEs. In total, 69 of the 498 participants reported a diagnosis of IBS (13.8%). BD was associated with significantly elevated rates of IBS compared to MDD (18.5% versus 10.1% respectively). After adjusting for age and sex, history of childhood sexual abuse was associated with increased rates of IBS in mood disorder participants [adjusted odds ratio (aOR) = 1.95]. In the MDD subgroup, ACEs (all categories and individual categories) were not associated with increased rates of IBS. In the BD subgroup, history of childhood sexual abuse was associated with significantly increased rates of IBS (38% versus 14%; aOR = 3.7). In summary, BD was associated with a higher prevalence of IBS compared to MDD. Additionally, history of sexual abuse was associated with an increased prevalence of IBS in BD, but not in MDD.

Publication types

Letter

MeSH terms

Adult
Adverse Childhood Experiences / trends*
Bipolar Disorder / diagnosis
Bipolar Disorder / psychology
Child
Cross-Sectional Studies
Depressive Disorder, Major / diagnosis
Depressive Disorder, Major / psychology
Female
Humans
Irritable Bowel Syndrome / diagnosis*
Irritable Bowel Syndrome / psychology*
Male
Middle Aged
Mood Disorders / diagnosis*
Mood Disorders / psychology*
Prevalence
Retrospective Studies
Sex Offenses / psychology
Sex Offenses / trends