A firehose for phospholipids

William A Prinz; James H Hurley

doi:10.1083/jcb.202003132

A firehose for phospholipids

J Cell Biol. 2020 May 4;219(5):e202003132. doi: 10.1083/jcb.202003132.

Authors

William A Prinz¹, James H Hurley^{2

3}

Affiliations

¹ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
² Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA.
³ Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA.

Abstract

All lipid transport proteins in eukaryotes are thought to shuttle lipids between cellular membranes. In this issue, Li et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202001161) show that Vps13 has a channel-like domain that may allow lipids to flow between closely apposed membranes at contact sites.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Membrane
Cryoelectron Microscopy*
Membranes
Mitochondrial Membranes
Phospholipids*

Substances

Phospholipids

Grants and funding

R01 GM111730/GM/NIGMS NIH HHS/United States