A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

Yueping Jiang; Min Liu; Haitao Liu; Shao Liu

doi:10.1007/s11101-020-09673-w

A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

Phytochem Rev. 2020;19(2):449-489. doi: 10.1007/s11101-020-09673-w. Epub 2020 Apr 24.

Authors

Yueping Jiang^{1

2

3}, Min Liu^{1

2

3}, Haitao Liu^{1

2

3}, Shao Liu^{1

2

3}

Affiliations

¹ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008 China.
² Institute of Hospital Pharmacy, Central South University, Changsha, 410008 China.
³ Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008 China.

Abstract

Abstract: Stephania tetrandra S. Moore (S. tetrandra) is distributed widely in tropical and subtropical regions of Asia and Africa. The root of this plant is known in Chinese as "Fen Fang Ji". It is commonly used in traditional Chinese medicine to treat arthralgia caused by rheumatism, wet beriberi, dysuria, eczema and inflamed sores. Although promising reports have been published on the various chemical constituents and activities of S. tetrandra, no review comprehensively summarizes its traditional uses, phytochemistry, pharmacology and toxicology. Therefore, the review aims to provide a critical and comprehensive evaluation of the traditional use, phytochemistry, pharmacological properties, pharmacokinetics and toxicology of S. tetrandra in China, and meaningful guidelines for future investigations.

Keywords: Chemical constituents; Pharmacological properties; Stephania tetrandra S. Moore; Toxicology; Traditional use.

Publication types

Review