Novel and established intestinal cell line models - An indispensable tool in food science and nutrition

Tomaz Langerholc; Petros A Maragkoudakis; Jan Wollgast; Lidija Gradisnik; Avrelija Cencic

doi:10.1016/j.tifs.2011.03.010

Novel and established intestinal cell line models - An indispensable tool in food science and nutrition

Trends Food Sci Technol. 2011 Nov:22:S11-S20. doi: 10.1016/j.tifs.2011.03.010. Epub 2011 Apr 9.

Authors

Tomaz Langerholc¹, Petros A Maragkoudakis², Jan Wollgast², Lidija Gradisnik³, Avrelija Cencic^{1

3}

Affiliations

¹ Dep. of Microbiology, Biochemistry, Molecular Biology and Biotechnology, Faculty of Agriculture and Life Science, University of Maribor, Pivola 10, 2311 Hoce, Slovenia.
² European Commission - Joint Research Centre - Institute for Health and Consumer Protection, Via Enrico Fermi 2749, 21027 Ispra (VA), Italy.
³ Dep. of Biochemistry and Nutrition, Faculty of Medicine, University of Maribor, Slomskov trg 15, 2000 Maribor, Slovenia.

Abstract

This review presents the applications of intestinal cell models of human and pig origin in food and nutritional sciences and highlights their potential as in vitro platforms for preclinical research. Intestinal cell models are used in studies of bioavailability, adsorption and transport in nutritional or toxicological settings, allergic effects of food components, as well as probiotics and/or host-pathogen gut interactions. In addition, this review discusses the advantages of using specialized and functional cell models over generic cancer-derived cell lines.

Publication types

Review