Relationship Between Disease Specific Quality of Life Measures, Physical Performance, and Activity in People with Intermittent Claudication Caused by Peripheral Artery Disease

Jonathan Golledge; Anthony S Leicht; Lisan Yip; Sophie E Rowbotham; Jenna Pinchbeck; Jason S Jenkins; Roslyn Clapperton; Matthew Dally-Watkins; Maria A Fiatarone Singh; Yorgi Mavros; Yian Noble; Marjan M Haghighi; Matthew Hollings; Belinda J Parmenter; Nicola W Burton

doi:10.1016/j.ejvs.2020.02.006

Relationship Between Disease Specific Quality of Life Measures, Physical Performance, and Activity in People with Intermittent Claudication Caused by Peripheral Artery Disease

Eur J Vasc Endovasc Surg. 2020 Jun;59(6):957-964. doi: 10.1016/j.ejvs.2020.02.006. Epub 2020 Apr 23.

Authors

Affiliations

¹ Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Australian Institute of Tropical Medicine, Townsville, Queensland, Australia; The Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Queensland, Australia. Electronic address: Jonathan.Golledge@jcu.edu.au.
² Sport and Exercise Science, James Cook University, Townsville, Queensland, Australia.
³ Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Australian Institute of Tropical Medicine, Townsville, Queensland, Australia.
⁴ Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Australian Institute of Tropical Medicine, Townsville, Queensland, Australia; The University of Queensland, UQ Centre for Clinical Research, Herston, QLD, 4029, Australia; Department of Vascular Surgery, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
⁵ Department of Vascular Surgery, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
⁶ The University of Queensland, UQ Centre for Clinical Research, Herston, QLD, 4029, Australia; Department of Vascular Surgery, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
⁷ Physical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, The University of Sydney School of Health Sciences, Faculty of Medicine and Health, Lidcombe, New South Wales, Australia; Hinda and Arthur Marcus Institute for Ageing Research, Boston, MA, USA.
⁸ Physical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, The University of Sydney School of Health Sciences, Faculty of Medicine and Health, Lidcombe, New South Wales, Australia.
⁹ Department of Exercise Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
¹⁰ School of Applied Psychology, Griffith University, Brisbane, Queensland, Australia.

PMID: 32336621
DOI: 10.1016/j.ejvs.2020.02.006

Abstract

Objective: The aims of this study were firstly to assess the correlation between disease specific measures of quality of life (QOL) and physical performance and activity, and secondly to identify demographic, clinical, functional, and physical activity measures independently associated with QOL in people with intermittent claudication.

Methods: This was a cross sectional observational study of 198 people with intermittent claudication caused by peripheral artery disease who were recruited prospectively. QOL was assessed with the intermittent claudication questionnaire (ICQ) and the eight-theme peripheral artery disease quality of life questionnaire. Physical performance was assessed with the six minute walk test (6MWT) and short physical performance battery (SPPB), and an accelerometer was used to measure seven day step count. The associations between QOL scores and 6MWT distance, SPPB scores and seven day step count were examined using Spearman Rho's (ρ) correlation and multivariable linear regression.

Results: ICQ scores were significantly correlated with 6MWT distance (ρ = 0.472, p < .001), all four SPPB scores (balance ρ = 0.207, p = .003; gait speed ρ = 0.303, p < .001; chair stand ρ = 0.167, p = .018; total ρ = 0.265, p < .001), and seven day step count (ρ = 0.254, p < .001). PADQOL social relationships and interactions (ρ = 0.343, p < .001) and symptoms and limitations in physical functioning (ρ = 0.355, p < .001) themes were correlated with 6MWT distance. The 6MWT distance was independently positively associated with ICQ and both PADQOL theme scores (ICQ: B 0.069, p < .001; PADQOL social relationships and interactions: B 0.077, p < .001; PADQOL symptoms and limitations in physical functioning: B 0.069, p < .001).

Conclusion: Longer 6MWT distance independently predicted better physical and social aspects of QOL in people with intermittent claudication supporting its value as an outcome measure.

Keywords: Peripheral artery disease; Physical activity; Physical performance; Quality of life.

Publication types

Multicenter Study
Observational Study

MeSH terms

Aged
Cross-Sectional Studies
Female
Humans
Intermittent Claudication / diagnosis*
Intermittent Claudication / etiology
Intermittent Claudication / physiopathology
Male
Middle Aged
Patient Reported Outcome Measures*
Peripheral Arterial Disease / complications*
Physical Functional Performance*
Prospective Studies
Quality of Life*
Walk Test