Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways

Nat Commun. 2020 Apr 24;11(1):1973. doi: 10.1038/s41467-020-15880-y.

Abstract

The genetics of quiescence is an emerging field compared to that of growth, yet both states generate spontaneous mutations and genetic diversity fueling evolution. Reconciling mutation rates in dividing conditions and mutation accumulation as a function of time in non-dividing situations remains a challenge. Nitrogen-starved fission yeast cells reversibly arrest proliferation, are metabolically active and highly resistant to a variety of stresses. Here, we show that mutations in stress- and mitogen-activated protein kinase (S/MAPK) signaling pathways are enriched in aging cultures. Targeted resequencing and competition experiments indicate that these mutants arise in the first month of quiescence and expand clonally during the second month at the expense of the parental population. Reconstitution experiments show that S/MAPK modules mediate the sacrifice of many cells for the benefit of some mutants. These findings suggest that non-dividing conditions promote genetic diversity to generate a social cellular environment prone to kin selection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coculture Techniques
  • DNA / metabolism
  • Flow Cytometry
  • Genetic Variation
  • Genotype
  • MAP Kinase Signaling System*
  • Mitosis*
  • Mutation*
  • Nitrogen / physiology*
  • Phenotype
  • Protein Serine-Threonine Kinases / genetics
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces / physiology*
  • Schizosaccharomyces pombe Proteins / genetics
  • Sequence Analysis, DNA
  • Signal Transduction
  • Stochastic Processes

Substances

  • Schizosaccharomyces pombe Proteins
  • DNA
  • Protein Serine-Threonine Kinases
  • Nitrogen