Concurrent presence of secretory carcinoma and Warthin's tumor in ipsilateral parotid gland

Oral Oncol. 2020 Oct:109:104691. doi: 10.1016/j.oraloncology.2020.104691. Epub 2020 Apr 21.

Abstract

Background: The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland.

Methods: The patient presented with increasingly painful enlargement of the left parotid gland. CT scan with contrast revealed a heterogeneous solid/cystic mass in the superficial lobe. Fine needle aspiration cytology favored pleomorphic adenoma (PA) and patient underwent superficial parotidectomy without complication.

Results: Final pathology revealed concomitant presence of SC and WT. Stains were positive for S100 and mammaglobin, and FISH revealed the presence of t(12;15) (p13;q25) translocation, resulting in the ETV6-NTRK3 fusion gene.

Conclusion: It is important for surgeons and pathologists to note the potential for co-existing benign and malignant pathology within the same salivary gland, as this can have an impact on management and prognosis for patients.

Keywords: Parotid gland; Salivary tumors; Secretory carcinoma; Synchronous; Warthin’s tumor.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adenolymphoma / diagnosis*
  • Biopsy, Fine-Needle
  • Carcinoma / diagnosis*
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neoplasms, Second Primary / diagnosis*
  • Parotid Neoplasms / diagnosis*
  • Salivary Gland Neoplasms / diagnosis
  • Tomography, X-Ray Computed