Design of Functional Magnetic Nanocomposites for Bioseparation

Colloids Surf B Biointerfaces. 2020 Jul:191:111014. doi: 10.1016/j.colsurfb.2020.111014. Epub 2020 Apr 15.

Abstract

Magnetic materials have been widely used in bioseparation in recent years due to their good biocompatibility, magnetic properties, and high binding capacity. In this review, we provide a brief introduction on the preparation and bioseparation applications of magnetic materials including the synthesis and surface modification of magnetic nanoparticles as well as the preparation and applications of magnetic nanocomposites in the separation of proteins, peptides, cells, exosomes and blood. The current limitations and remaining challenges in the fabrication process of magnetic materials for bioseparation will be also detailed.

Keywords: bioseparation; magnetic nanoparticles; materials; nanocomposites; synthesis.

Publication types

  • Review

MeSH terms

  • Exosomes / chemistry*
  • Humans
  • Magnetic Phenomena
  • Magnetite Nanoparticles / chemistry
  • Neoplastic Cells, Circulating / pathology*
  • Peptides / chemistry
  • Peptides / isolation & purification*
  • Proteins / chemistry
  • Proteins / isolation & purification*

Substances

  • Magnetite Nanoparticles
  • Peptides
  • Proteins