Cell-penetrating peptides: two faces of the same coin

Giovanna Maria Pierantoni; Simona Paladino

doi:10.1042/BCJ20200006

Cell-penetrating peptides: two faces of the same coin

Biochem J. 2020 Apr 30;477(8):1363-1366. doi: 10.1042/BCJ20200006.

Authors

Giovanna Maria Pierantoni¹, Simona Paladino¹

Affiliation

¹ Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Pansini, 5, 80131 Naples, Italy.

PMID: 32322896
DOI: 10.1042/BCJ20200006

Abstract

Cell-penetrating peptides (CPPs) are short peptides able to cross the cellular membranes without any interaction with specific receptors. Thanks to their ability to transport various cargo inside the cells are emerged as powerful therapeutic agents alternative to small molecules. In recent years, numerous preclinical studies provided promising results for the treatment of various human diseases. Several CPP-conjugated compounds are under clinical trials.

Keywords: cancer; cell penetrating peptide; lipid microdomains; membranes; therapeutics; trafficking.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
Cell Membrane / metabolism
Cell-Penetrating Peptides / administration & dosage
Cell-Penetrating Peptides / chemistry
Cell-Penetrating Peptides / metabolism*
Drug Therapy
Humans

Substances

Cell-Penetrating Peptides