Background: Previous clinical evaluations have demonstrated a difference in eye movements in healthy children compared to children with vertigo without vestibular pathology. It has also been previously shown that accommodation and vergence responses can be measured with remote haploscopic photo refractor (RHP) devices. We have developed a method, called REMOBI (patent US8851669, WO2011073288) that allows us to test eye movements in three-dimensional space without decoupling vergence and accommodation.[1].
Methods: We compared standard clinical testing of vergence and accommodation responses separately, with laboratory simultaneous measurement of vergence and accommodation in healthy children, 31 with vertigo (mean age 11 SD +/- 3.02), and 53 without (mean age 10 SD +/- 3.29). Children diagnosed with vertigo then underwent orthoptic rehabilitation for vergence and accommodation disorders and were re-evaluated twice using laboratory testing: once after 12 sessions and once 3-months after completing the sessions.
Findings: Using the clinical tests, significant differences were found between the vertigo and healthy groups: D' (break point of divergence near), D2 (second measurement of divergence after convergence far), D2' (second measurement of divergence after convergence near), C (break point of convergence far), and C' (break point of convergence near). However, no significant differences in accommodation or vergence were seen between the two groups using laboratory tests (RHP and REMOBI). Further, there was no difference in laboratory measurements in children with vertigo before, after, and 3 months after clinical rehabilitation.
Interpretation: We postulate the difference in these two tests is because the laboratory tests are more accurate and more realistic because they measure accommodation and vergence simultaneously, as it incorporates a stronger binocular coordination response not appreciated by current clinical measurements. Further studies should be conducted to evaluate whether clinicians should consider adding objective measurements, such as using a RHP device, when diagnosing patients with vergence and accommodation disorders, to avoid prescribing costly and timely rehabilitation programs that do not improve accommodative and vergence movements.
Funding: We thank the Fulbright Foundation, along with the University of California, San Francisco, for the research fellowship to Lindsey M Ward. This study is part of the PHRC VERVE, hospital research program, run at the hospital Robert Debré and supported by Direction de la Recherche Clinique, Assistance Publique, France. The funding sources had no involvement in the study design; collection, analysis, and interpretation of data; writing of the manuscript; and in the decision to submit the manuscript for publication.
Keywords: Oculomotor system; Orthoptic rehabilitation; Orthoptics; Pediatric neurology; Vergence and accommodation disorders; Vertigo.
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