Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Ki Hoon Kim; Jeong Hyun Jo; Hye Jin Cho; Tae Sub Park; Tae Min Kim

doi:10.1186/s42826-020-00043-3

Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Lab Anim Res. 2020 Apr 15:36:10. doi: 10.1186/s42826-020-00043-3. eCollection 2020.

Authors

Ki Hoon Kim¹, Jeong Hyun Jo¹, Hye Jin Cho², Tae Sub Park^{1

2}, Tae Min Kim^{1

2}

Affiliations

¹ Graduate School of International Agricultural Technology, Pyeongchang, South Korea.
² 2Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do 25354 South Korea.

Abstract

Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived EVs have several advantages such as reduced risk of rejection, less oncogenic potential, ease of long-term storage, lower chance of thromboembolism, and readiness for immediate use. Recent studies have demonstrated that EVs from stem cells, mostly from mesenchymal stem cells (MSCs) from various tissues, have anti-inflammatory, anti-oxidative, anti-apoptotic, and proliferative role in injured organs including osteoarthritic lesions. Herein, we provide a review about the up-to-date studies in preclinical application of stem cell-derived EVs in osteoarthritis animal arthritis models.

Keywords: EVs (extracellular vesicles); MSCs (Mesenchymal stem cells); OA (osteoarthritis).

Publication types

Review