Metabolic reprogramming plays an important role in the occurrence, drug resistance and recurrence of acute myeloid leukemia (AML). Warburg effect is considered to be the most fundamental metabolic alternation in the process of tumor transformation. The enhancement of glycolytic activation was being found in most malignancies including AML, which promotes anabolism and closely relates with the occurrence and development of tumors. Each metabolic process of glycolysis pathway is catalyzed by specific enzymes. The dependence of AML cells on glycolysis makes targeting inhibition of related catalytic enzymes and interference with glycolysis process a promising therapeutic option. In this review, the recent advances in glycolysis pathway-related targeted therapy in AML are summarized.
题目: 糖酵解途径相关靶向治疗在急性髓系白血病中的最新研究进展.
摘要: 代谢重编程在急性髓系白血病（acute myeloid leukemia，AML）的发生、耐药、复发过程中都发挥了重要的作用。瓦尔堡效应被认为是肿瘤转化过程中最基本的代谢转变，在绝大多数恶性肿瘤中发现了糖酵解活性增强，包括AML，其促进合成代谢，与肿瘤的发生发展息息相关。糖酵解途径的每一个代谢过程都由特定的酶所催化，AML细胞对糖酵解的依赖性使靶向抑制相关催化酶从而干扰糖酵解过程有望成为新的治疗选择。本文立足国内外重要研究，就糖酵解途径相关靶向治疗在AML治疗中的最新研究进展作一综述。.