Assessment of expression of podoplanin in odontogenic tumors and cysts-An immunohistochemical study

Rohit Singh; Malwika Sisodia; Ranjan Sengupta; Annu Prakash Bhindwar; Karuna Bharti; Md Abu Nafe

doi:10.4103/jfmpc.jfmpc_1092_19

Assessment of expression of podoplanin in odontogenic tumors and cysts-An immunohistochemical study

J Family Med Prim Care. 2020 Feb 28;9(2):804-806. doi: 10.4103/jfmpc.jfmpc_1092_19. eCollection 2020 Feb.

Authors

Rohit Singh¹, Malwika Sisodia², Ranjan Sengupta², Annu Prakash Bhindwar², Karuna Bharti², Md Abu Nafe³

Affiliations

¹ Department of Prosthodontics, Crown Bridge and Implantology, Patna Dental College and Hospital, Patna, India.
² Department of Conservative Dentistry and Endodontics, Mithila Minority Dental College, Bihar, India.
³ Department of Periodontology, MMDCH Dental College, Darbhanga, Bihar, India.

Abstract

Aim: The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts.

Materials and methods: It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous cysts (DC), 8 cases of radicular cysts (RC) and 8 dental follicles (DF) as controls which were immunohistochemically evaluated using an antibody against podoplanin.

Results: Immunostaining intensity, % of PPC and total score of ameloblastoma was higher than DC and DF but less than KCOT (t- 1.48). When DC was compared with KCOT and RC, the podoplanin expression was significantly higher with DC (P < 0.05). The podoplanin expression was comparatively higher with KCOT as compared to RC and DC. OT (t-4.40) revealed higher podoplanin expression as compared to OC and DF (t-5.54).

Conclusion: There was significantly higher expression of podoplanin in cases of ameloblastoma and KCOT as compared to the RC, DC and DF. Podoplanin may be considered as a useful marker to delineate the aggressiveness of ameloblastoma and KCOT.

Keywords: Ameloblastoma; keratocystic odontogenic tumor; podoplanin.