Sundarbans mangrove forest, the world's largest continuous mangrove forests expanding across India and Bangladesh, in recent times, is immensely threatened by degradation stress due to natural stressors and anthropogenic disturbances. The degradation across the 19 mangrove forests in Indian Sundarbans was evaluated by eight environmental criteria typical to mangrove ecosystem. In an attempt to find competent predictors for mangrove ecosystem degradation, key eco-physiological resilience trait complex specific for mangroves from 4922 individuals for physiological analyses with gene expression and 603 individuals for leaf tissue distributions from 16 mangroves and 15 associate species was assessed along the degradation gradient. The degradation data was apparently categorized into four and CDFA discriminates 97% of the eco-physiological resilience data into corresponding four groups. Predictive Bayesian regression models and mixed effects models indicate osmolyte accumulation and thickness of water storage tissue as primary predictors of each of the degradation criteria that appraise the degradation status of mangrove ecosystem. RDA analyses well represented response variables of degradation explained by explanatory resilience variables. We hypothesize that with the help of our predictive models the policy makers could trace even the cryptic process of mangrove degradation and save the respective forests in time by proposing appropriate action plans.