Metformin, as a first-line drug in the treatment of type 2 diabetes, has been proved to be safe and effective. In recent years, epidemiological studies have found that metformin can inhibit the proliferation and metastasis of lung cancer cells, and is expected to become a new anti-lung cancer drug. Lung cancer is a disease that seriously endangers human health, its morbidity and mortality have been ranked first among all malignant tumors, and the prognosis is poor. In recent years, a great deal of evidence shows that metformin can reduce the risk and mortality of tumors such as lung cancer. Its mechanisms mainly include activating adenosine monophosphate-activated protein kinase pathway, improving hyperinsulinemia and insulin resistance, promoting lung cancer cell apoptosis and inhibiting related inflammatory response. The aim of this article is to reviews the study of metformin on lung cancer.
【中文题目：二甲双胍抗肺癌机制研究进展】 【中文摘要：二甲双胍作为治疗2型糖尿病的一线用药，安全性及有效性得到证实。近年来流行病学研究发现二甲双胍具有抑制肺癌细胞增殖及转移等特性，有望成为一种新的抗肺癌药物。肺癌是一种严重危害人类健康的疾病，其发病率和死亡率一直居所有恶性肿瘤之首，且预后差。近年来大量证据表明二甲双胍能降低肺癌等肿瘤的发病风险及死亡率，其机制主要包括激活单磷酸腺苷活化的蛋白激酶通路、改善高胰岛素血症及胰岛素抵抗、促进肺癌细胞凋亡、抑制相关炎症反应等。本文就二甲双胍对肺癌的研究做一综述。】 【中文关键词：肺肿瘤；二甲双胍；糖尿病】.
Keywords: Diabetes mellitus; Lung neoplasms; Metformin.