Hedgehog Signaling in Organogenesis and the Tumor Microenvironment

Tsuyoshi Shimo

doi:10.3390/ijms21082788

Hedgehog Signaling in Organogenesis and the Tumor Microenvironment

Int J Mol Sci. 2020 Apr 17;21(8):2788. doi: 10.3390/ijms21082788.

Author

Tsuyoshi Shimo¹

Affiliation

¹ Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan.

Abstract

The Hedgehog signaling pathway was first discovered in 1980 during a large-scale genetic screening seeking to find mutations that affect larval body segment development in the fruit fly, Drosophila melanogaster [...].

Publication types

Editorial
Introductory Journal Article

MeSH terms

Animals
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Hedgehog Proteins / metabolism*
Humans
Neoplasms / metabolism*
Organogenesis*
Signal Transduction
Tumor Microenvironment

Substances

Hedgehog Proteins