Recently, healthcare has undergone a sector-wide transformation thanks to advances in computing, networking technologies, big data, and artificial intelligence. Healthcare is not only changing from being reactive and hospital-centered to preventive and personalized, but it is also changing from being disease focused to well-being centered. Healthcare systems, as well as fundamental medicine research, are becoming smarter and enabled in biomedical engineering. This special issue on "Selected Papers from 2019 IEEE Eurasia Conference on Biomedical Engineering, Healthcare, and Sustainability (IEEE ECBIOS 2019)" selected nine excellent papers from 160 papers presented at IEEE ECBIOS 2019 on the topics of environmental health sciences and public health. Our aim is to encourage scientists to publish their experimental and theoretical research to promote scientific predictions and impact assessments of global change and development.