Glucose Metabolism Takes Center Stage in Epithelial-Mesenchymal Plasticity

Khalil Kass Youssef; M Angela Nieto

doi:10.1016/j.devcel.2020.03.021

Glucose Metabolism Takes Center Stage in Epithelial-Mesenchymal Plasticity

Dev Cell. 2020 Apr 20;53(2):133-135. doi: 10.1016/j.devcel.2020.03.021.

Authors

Khalil Kass Youssef¹, M Angela Nieto²

Affiliations

¹ Instituto de Neurociencias CSIC-UMH, Sant Joan d'Alacant 03550, Spain.
² Instituto de Neurociencias CSIC-UMH, Sant Joan d'Alacant 03550, Spain. Electronic address: anieto@umh.es.

PMID: 32315608
DOI: 10.1016/j.devcel.2020.03.021

Abstract

Aerobic glycolysis, or Warburg effect, has been associated with pathologies such as cancer. In this issue of Developmental Cell, Bhattacharya et al. show that aerobic glycolysis is required for neural crest migration in development. These findings point to a link between glucose metabolism and epithelial-mesenchymal plasticity in development and disease.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Glucose
Glycolysis*
Humans
Neoplasms*
Neural Crest
Signal Transduction

Substances

Glucose