The Peroxisome: A New Player in Intestinal Epithelial Repair

Dev Cell. 2020 Apr 20;53(2):131-132. doi: 10.1016/j.devcel.2020.03.023.

Abstract

Stem cells drive tissue regeneration due to their capacity to proliferate and differentiate in response to damage. In this issue of Developmental cell, Du et al. reveal a mechanism regulating intestinal stem cell differentiation and epithelial repair following injury, which depends on peroxisomes and their action inducing JAK/Stat signaling and Sox21a.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Differentiation
  • Intestines
  • Janus Kinases* / metabolism
  • Peroxisomes
  • STAT Transcription Factors* / metabolism

Substances

  • STAT Transcription Factors
  • Janus Kinases