HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures

Shanyu Chen; Xiaoyu He; Ruilin Li; Xiaohong Duan; Beifang Niu

doi:10.1093/bioinformatics/btaa258

HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures

Bioinformatics. 2020 Jun 1;36(12):3944-3946. doi: 10.1093/bioinformatics/btaa258.

Authors

Shanyu Chen^{1

2}, Xiaoyu He^{1

2}, Ruilin Li¹, Xiaohong Duan³, Beifang Niu^{1

2

3}

Affiliations

¹ Computer Network Information Center, Chinese Academy of Sciences.
² University of Chinese Academy of Sciences, Beijing 100190, China.
³ ChosenMed Technology (Beijing) Co. Ltd, Beijing 100176, China.

PMID: 32315389
DOI: 10.1093/bioinformatics/btaa258

Abstract

Motivation: HotSpot3D is a widely used software for identifying mutation hotspots on the 3D structures of proteins. To further assist users, we developed a new HotSpot3D web server to make this software more versatile, convenient and interactive.

Results: The HotSpot3D web server performs data pre-processing, clustering, visualization and log-viewing on one stop. Users can interactively explore each cluster and easily re-visualize the mutational clusters within browsers. We also provide a database that allows users to search and visualize proximal mutations from 33 cancers in the Cancer Genome Atlas.

Availability and implementation: http://niulab.scgrid.cn/HotSpot3D/.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computers
Databases, Factual
Internet
Mutation
Proteins* / genetics
Software*

Substances

Proteins