Targeting FOXP3 complex ensemble in drug discovery

Jingyao Huang; Shuoyang Wang; Yuxin Jia; Yujia Zhang; Xueyu Dai; Bin Li

doi:10.1016/bs.apcsb.2019.11.010

Targeting FOXP3 complex ensemble in drug discovery

Adv Protein Chem Struct Biol. 2020:121:143-168. doi: 10.1016/bs.apcsb.2019.11.010. Epub 2020 Jan 7.

Authors

Jingyao Huang¹, Shuoyang Wang¹, Yuxin Jia¹, Yujia Zhang¹, Xueyu Dai¹, Bin Li¹

Affiliation

¹ Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

PMID: 32312420
DOI: 10.1016/bs.apcsb.2019.11.010

Abstract

Forkhead Box P3 (FOXP3) is a key transcriptional regulator of regulatory T cells (Tregs), especially for its function of immune suppression. The special immune suppression function of Tregs plays an important role in maintaining immune homeostasis, and is related to several diseases including cancer, and autoimmune diseases. At the same time, FOXP3 takes a place in a large transcriptional complex, whose stability and functions can be controlled by various post-translational modification. More and more researches have suggested that targeting FOXP3 or its partners might be a feasible solution to immunotherapy. In this review, we focus on the transcription factor FOXP3 in Tregs, Treg functions in diseases and the FOXP3 targets.

Keywords: Drug discovery; FOXP3; Immune therapy; Post-translational modification; Treg.

Publication types

Review

MeSH terms

Acetylation / drug effects
Autoimmune Diseases / drug therapy*
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology
Autoimmune Diseases / pathology
Drug Discovery
Histone Deacetylase Inhibitors / therapeutic use*
Homeostasis / drug effects
Homeostasis / genetics
Homeostasis / immunology
Humans
Hypersensitivity / drug therapy*
Hypersensitivity / genetics
Hypersensitivity / immunology
Hypersensitivity / pathology
Immunologic Factors / therapeutic use*
Neoplasms / drug therapy*
Neoplasms / genetics
Neoplasms / immunology
Neoplasms / pathology
Organ Transplantation
Phosphorylation / drug effects
Protein Domains
Protein Kinase Inhibitors / therapeutic use*
Protein Processing, Post-Translational*
T-Lymphocytes, Regulatory / drug effects
T-Lymphocytes, Regulatory / immunology
T-Lymphocytes, Regulatory / pathology
Ubiquitination / drug effects

Substances

Histone Deacetylase Inhibitors
Immunologic Factors
Protein Kinase Inhibitors