The role of SUMOylation during development

Biochem Soc Trans. 2020 Apr 29;48(2):463-478. doi: 10.1042/BST20190390.

Abstract

During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a 'molecular glue' by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals.

Keywords: SUMO; development; ubiquitin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Differentiation
  • Cell Nucleus / metabolism
  • Chromatin / metabolism
  • Cytoplasm / metabolism
  • Gene Expression Regulation, Developmental*
  • Germ Cells
  • Humans
  • Mice
  • Oogenesis
  • Small Ubiquitin-Related Modifier Proteins / chemistry*
  • Spermatogenesis
  • Sumoylation*
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • Small Ubiquitin-Related Modifier Proteins
  • Transcription Factors